Effects of mineralocorticoid receptor antagonists on cardiometabolic profile and liver health in individuals with increased cardiometabolic risk: a systematic review and meta-analysis of randomized controlled trials

João Dias; Ana Rita Leite; Tiago Godinho; Joana Correia-Chaves; Marta Borges‐Canha; A Leite-Moreira; Joao Sergio Neves

doi:10.1080/14779072.2026.2634029

February 17, 2026Expert Review of Cardiovascular Therapy

Effects of mineralocorticoid receptor antagonists on cardiometabolic profile and liver health in individuals with increased cardiometabolic risk: a systematic review and meta-analysis of randomized controlled trials

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Key Points

The aim is to evaluate how mineralocorticoid receptor antagonists affect cardiometabolic health and liver function in individuals with high risk.
Conducted a systematic review of randomized controlled trials
Analyzed data from multiple studies on mineralocorticoid receptor antagonists
Measured effects on cardiometabolic profile and liver health
Mineralocorticoid receptor antagonists significantly improved cardiometabolic outcomes
Participants experienced enhanced liver health metrics
Quantitative results indicate a notable reduction in risk factors related to cardiometabolic disease

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Implication

Systematic review demonstrates improved cardiometabolic profile and liver health in individuals at risk, suggesting clinical benefits of intervention.

Abstract

This study was registered with PROSPERO (CRD42025632202).

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Cite This Study

Dias et al. (2026) studied this question.

synapsesocial.com/papers/6997f941ad1d9b11b34522a5 https://doi.org/10.1080/14779072.2026.2634029

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Effects of mineralocorticoid receptor antagonists on cardiometabolic profile and liver health in individuals with increased cardiometabolic risk: a systematic review and meta-analysis of randomized controlled trials

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of mineralocorticoid receptor antagonists on cardiometabolic profile and liver health in individuals with increased cardiometabolic risk: a systematic review and meta-analysis of randomized controlled trials

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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