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This review highlights advances in antidepressant therapies, indicating a need for improved clinical guidelines.
Newer antidepressants represent a shift beyond conventional approaches, offering rapid symptom relief and potential cognitive or metabolic benefits. However, limited guideline integration, insufficient long-term data, and implementation barriers restrict their clinical uptake. Clearer sequencing strategies and harmonized recommendations are needed to support more individualized depression management.
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Cuomo et al. (2026) studied this question.
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