Control over stereogenic centres beyond tetracoordination

Key Points

• The aim is to explore higher-order stereogenic centres and their potential in expanding stereochemical space.
• Reviewed existing literature on stereogenic centres
• Analyzed the synthesis methods for penta- and hexacoordinate centres
• Discussed applications of these centres in various fields.
• Identified the ability of higher-order centres to encode more than two stereoisomers
• Showcased various synthesis strategies for these centres
• Highlighted potential applications in biomedical and material sciences.