Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Peltine A Ndifon; Emma Pinder; Christopher Slater; Christopher J. Clemett; Auska A. T. McRobbie; Samuel P. Rayner; Shalith Wickramarachchi; Karima Bertal-Ngaage; Simon J. Allison; Rebecca Dowey; Jane Harmer; Martin Carr; Anthony J. Slate; Roger M. Phillips; Jonathan A. Butler; Craig R. Rice; Martina Whitehead

doi:10.1039/d6dt00038j

January 1, 2026Dalton TransactionsOpen Access

Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

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Key Points

Investigate the synthesis and biological properties of a silver helicate, focusing on its antimicrobial effects.
Synthesis of a dinuclear silver helicate
Characterisation of its structure and properties
Assessment of cytotoxicity against cancer cell lines
Evaluation of antimicrobial activity against various bacteria, including MRSA
The silver helicate exhibited significant cytotoxic effects on cancer cell lines.
Enhanced antimicrobial activity was observed against MRSA compared to traditional silver cations.
MRSA was more sensitive to the silver helicate than other tested bacteria, E. coli and P. aeruginosa.

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Implication

Demonstrates enhanced antimicrobial activity of a silver helicate against MRSA, suggesting potential therapeutic applications.

Abstract

A dinuclear double Ag + helicate demonstrated cytotoxicity against cancer cell lines and antimicrobial activity against E. coli , P. aeruginosa and S. aureus , with the latter being substantially more sensitive to the complex compared to silver cations.

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Ndifon et al. (2026) studied this question.

synapsesocial.com/papers/6997f9ddad1d9b11b34529eb https://doi.org/10.1039/d6dt00038j

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Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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