Design and Antimicrobial evaluation of 1-(2-(2,3,5-triphenylcyclopenta-2,4-dien-1-yl)ethyl)piperazine and their derivatives

M. Arockia doss; R. Rajkumar; A. Prabhakaran; E. Dhineshkumar; D. Uma

doi:10.5281/zenodo.18684706

April 2, 2020Open Access

Design and Antimicrobial evaluation of 1-(2-(2,3,5-triphenylcyclopenta-2,4-dien-1-yl)ethyl)piperazine and their derivatives

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Key Points

The research aims to design new piperazine derivatives and evaluate their antimicrobial activity.
Synthesis of six 1,2,4,5-tetrasubstituted imidazoles through multicomponent cyclo-condensation.
Screening for antibacterial activity against S. aureus, S. typhi, E. coli, and Pseudomonas.
Screening for antifungal activity against A. niger, C. albicans, Rhizopus sp, and Mucor.
The synthesized compounds demonstrated antibacterial effects against all tested strains.
Enhanced antifungal activity was observed for the synthesized derivatives.

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Implication

Multicomponent synthesis of imidazoles shows enhanced antimicrobial activity against various pathogens, suggesting potential therapeutic applications.

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doss et al. (2020) studied this question.

synapsesocial.com/papers/6997fa5aad1d9b11b34538de https://doi.org/10.5281/zenodo.18684706

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Design and Antimicrobial evaluation of 1-(2-(2,3,5-triphenylcyclopenta-2,4-dien-1-yl)ethyl)piperazine and their derivatives

Key Points

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Implication

Abstract

Discussion

Cite This Study

Design and Antimicrobial evaluation of 1-(2-(2,3,5-triphenylcyclopenta-2,4-dien-1-yl)ethyl)piperazine and their derivatives

Key Points

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Abstract

Discussion

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