Review explores c-di-GMP regulation of flagellar motility in bacteria, suggesting new models of control.
ABSTRACT c-di-GMP-mediated control of bacterial motility has been studied in some depth, but many questions remain. N. Bhattarai, W. Guo, J. D. Partridge, R. M. Harshey (J Bacteriol 207:e00353-25, 2025, https://doi.org/10.1128/jb.00353-25 ) review the current state of the field, present a new 2-step model for the control of flagellar motility, and test the first step of this model. Their model incorporates a plethora of data from different labs, including new structural insights of flagellar motor structure, to test and present a compelling model of by YcgR::c-di-GMP-mediated motility control.
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George A. O’Toole (2026) studied this question.
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