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February 20, 2026Advanced ScienceOpen Access

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

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Authors

MSMarie SabatierMKMayher KaurMCMilena Chaufan

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Overview

Demonstrates altered metastatic features in metastatic triple-negative breast cancer due to GPX4 inhibitor resistance, suggesting implications for therapy.

Key Points

  • The research aims to explore how GPX4 inhibitor resistance affects metastatic features in triple-negative breast cancer.
  • Cultured triple-negative breast cancer cell lines with GPX4 inhibitors
  • Generated GPX4 inhibitor-resistant cell lines (M231, 4T1)
  • Analyzed metabolic and lipidomic profiles of tumors from resistant cells
  • GPX4i-resistant tumors exhibited unique metabolic and lipidomic profiles
  • Resistant tumors were associated with a shift towards an epithelial-like state
  • Resistant cells formed fewer spontaneous metastases from primary tumors
  • No differences observed in overall metastatic burden after intravenous injection

Cite This Study

Sabatier et al. (2026) studied this question.

synapsesocial.com/papers/6997fa80ad1d9b11b3453bdchttps://doi.org/10.1002/advs.202523198
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