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February 21, 2026Biophysical Journal0 citations

image-based analysis of genome fractality during cell cycle phases

BPS2026 – Image-based analysis of the genome’s fractality during the cell cycle

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Authors

SLSuho LeeXLXutong LiuIZIvan Ziabkin

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Overview

Study reveals distinct fractal metrics of genome spatial organization in live cells during the cell cycle, highlighting key phases.

Key Points

  • Investigate how the genome's spatial organization varies during the cell cycle using fractal analysis.
  • Used spinning disk confocal microscopy to capture images of live human cell nuclei
  • Compared various image-based fractal analyses including lacunarity and multifractal spectrum
  • Analyzed changes in genome organization across different phases of the cell cycle
  • Fractal metrics vary significantly, indicating unique features of genome spatial organization
  • Consistent trends observed: genome is compact in early G1, decondenses in G1, and condenses again in S and G2 phases
  • Discrepancies between fractal measurement techniques reconciled through comprehensive analysis

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac29f0https://doi.org/10.1016/j.bpj.2025.11.2222
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