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The study examines mechanisms behind trogocytosis in macrophages and its effects on membrane exchange.

February 21, 2026Biophysical Journal

BPS2026 – Messy eaters: Mechanisms of trogocytic membrane exchange in macrophages

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The study examines mechanisms behind trogocytosis in macrophages and its effects on membrane exchange.
Utilized flow cytometry to analyze cell interactions.
Implemented high-resolution confocal microscopy for imaging.
Employed focused ion beam scanning electron microscopy for structural analysis.
Macrophages preferentially engulf stiff cancer cells and trogocytose soft cells.
Cross-dressing occurs when macrophages display proteins from target cells.
Membrane exchange efficiency is influenced by target cell biophysical properties.

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Implication

Experiments reveal that macrophages phagocytose stiff cancer cells while trogocytosing soft ones, indicating biophysical influences on cell interactions.

Cite This Study

Cornell et al. (2026) studied this question.

synapsesocial.com/papers/69990e015b97ab4c14ac2e9b https://doi.org/10.1016/j.bpj.2025.11.1609

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Implication

Experiments reveal that macrophages phagocytose stiff cancer cells while trogocytosing soft ones, indicating biophysical influences on cell interactions.

BPS2026 – Messy eaters: Mechanisms of trogocytic membrane exchange in macrophages

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Discussion

Implication

Cite This Study

BPS2026 – Messy eaters: Mechanisms of trogocytic membrane exchange in macrophages

Key Points

Discussion

Implication

Cite This Study

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