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February 21, 2026Biophysical Journal

BPS2026 – Rapfold: Relative accessibility-enhanced predictor for membrane protein structures

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Authors

KKKai KangSCSong Chen

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Overview

RAPFold improves prediction accuracy for membrane proteins, suggesting better modeling of transmembrane topology.

Key Points

  • To enhance the prediction of membrane protein structures using a specialized computational framework.
  • Developed RAPFold based on OpenFold for membrane proteins
  • Integrated Relative Lipid Accessibility and Relative Solvent Accessibility
  • Constructed a virtual lipid bilayer for protein orientation
  • Back-propagated gradients for optimization of structure predictions
  • RAPFold significantly improves prediction accuracy for certain membrane proteins
  • Predicted structures align more closely with the physicochemical properties of lipid membranes

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69990e015b97ab4c14ac2f88https://doi.org/10.1016/j.bpj.2025.11.485
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