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February 21, 2026Biophysical Journal0 citations

Membrane Activity Reduces Selectivity of Antimicrobial Peptides via Biophysical Interactions

BPS2026 – Reduced selectivity of antimicrobial peptides by strong membrane permeabilization activity

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Authors

KBKatharina BeckJNJanina NandyMHMaria Hoernke

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Overview

Investigating cyclic peptides reveals reduced selectivity in antimicrobial activity by inducing membrane permeabilization.

Key Points

  • To understand how the structural arrangement of cyclic peptides affects their selectivity as antimicrobial agents.
  • Compared two cyclic peptides differing in tryptophan and arginine arrangements.
  • Utilized various types of model membranes for interaction studies.
  • Employed multiple biophysical methods to analyze peptide behavior.
  • Cyclic peptides showed variable selectivity based on membrane types.
  • Larger hydrophobic surface led to more efficient vesicle fusion and leakage.
  • Modeling indicates that hydrophobic residues decrease selectivity in antimicrobial peptides.

Cite This Study

Beck et al. (2026) studied this question.

synapsesocial.com/papers/69990e0a5b97ab4c14ac3080https://doi.org/10.1016/j.bpj.2025.11.592
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