Role of Prophylactic Antibiotics in Patients Undergoing EUS-Directed Transgastric Interventions (EDGI) in Roux-en-Y Gastric Bypass and EUS-Gastroenterostomy (EUS-GE)

The infection risk associated with endoscopic ultrasound-directed transgastric intervention (EDGI) and endoscopic ultrasound guided gastroenterostomy (EUS-GE) is unknown. We aim to investigate the effect of prophylactic antibiotics in EDGI and EUS-GE on infection-related outcomes. A multi-center, retrospective chart review was conducted on patients who had undergone EDGI or EUS-GE between June 2017 and September 2023. Statistical significance was set at p<0.05. A total of 263 patients (147 EUS-GE, 116 EDGI) were identified. Prophylactic antibiotics were given in 58.9% of patients. There was no significant difference in the rate of transient (17.4% vs 12.0%, p=0.23) or persistent signs of infection (4.5% vs 3.7%, p=1.00) in patients with and without prophylactic antibiotics, respectively. The length of stay and readmission rates were also not significantly different between the two groups. Prophylactic antibiotics for EDGI and EUS-GE did not significantly improve infection-related outcomes.