Key result
Prolonged QRS duration in acute myocarditis is linked to ~8% higher in-hospital adverse events per millisecond.
Why the study?
The prognosis of acute myocarditis is difficult to predict due to its variable presentation, necessitating identification of early prognosticators in hospitalized patients.
Does prolonged QRS duration at admission predict adverse in-hospital outcomes in patients with acute myocarditis?
Observational (n=80)
Yes
Does prolonged QRS duration at admission predict adverse in-hospital outcomes in patients with acute myocarditis?
Prolonged QRS duration (≥130 ms) at admission is a simple, readily available ECG marker that strongly predicts adverse in-hospital outcomes in patients with acute myocarditis, identifying high-risk patients who may need early mechanical circulatory support.
Prolonged QRS may aid risk stratification in acute myocarditis; leaves open whether it should guide management.
Background: The prognosis of acute myocarditis (AM) is difficult to predict due to its variable presentation. We investigated the prognosticators of AM patients requiring hospitalization. Methods and Results: We conducted a multicenter observational study including 80 hospitalized AM patients. The primary endpoint was a composite of all-cause death, heart transplantation, and implantation of ventricular assist devices during the index hospitalization. Thirteen (16%) patients reached the endpoint. Longer QRS duration at admission independently predicted adverse outcomes, with an optimal cut-off of 130 ms. Conclusions: Prolonged QRS duration at admission might predict in-hospital prognosis in AM patients regardless of whether or not it was fulminant.
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Yoshida et al. (2026) conducted an observational in Acute myocarditis (n=80). Prolonged QRS duration at admission vs. Shorter QRS duration was evaluated on Composite of all-cause death, heart transplantation, and implantation of ventricular assist devices during the index hospitalization (OR 1.08, 95% CI 1.03-1.16). Prolonged QRS duration at admission independently predicted adverse in-hospital outcomes in patients with acute myocarditis, with each 1 ms increase associated with a higher risk of events (OR 1.08).
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