Endogenous DNA Damage and Its Role in Human Disease

Eva-Maria Bryan; Clare Lauderback

doi:10.1021/acs.chemrestox.5c00539

February 18, 2026Chemical Research in ToxicologyOpen Access

Endogenous DNA Damage and Its Role in Human Disease

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Key Points

The aim is to understand how endogenous DNA damage contributes to mutation, genomic instability, and human diseases like cancer.
Analyzed chemical diversity in DNA damage
Identified metabolic drivers of DNA damage
Examined limits of DNA repair mechanisms
Endogenous DNA damage significantly influences mutation rates
Varied metabolic factors impact cancer risk
New biomarkers can be developed based on DNA damage patterns

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Implication

New insights show endogenous DNA damage affects mutation risk in humans, suggesting implications for disease management.

Abstract

Endogenous DNA damage from metabolism and genome dynamics drives mutation, instability, and disease. New insights from ACS Fall 2025 reveal chemical diversity, metabolic drivers, and repair limits that shape cancer risk and biomarker development.

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Cite This Study

Bryan et al. (2026) studied this question.

synapsesocial.com/papers/69994b64873532290d01f849 https://doi.org/10.1021/acs.chemrestox.5c00539

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Endogenous DNA Damage and Its Role in Human Disease

Key Points

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Implication

Abstract

Discussion

Cite This Study

Endogenous DNA Damage and Its Role in Human Disease

Key Points

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Implication

Abstract

Discussion

Cite This Study

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