Findings identify the C5a-DRP1 axis promoting necroptosis in dry eye, suggesting new therapeutic targets.
Our findings identify the intracellular C5a-mtC5aR1-DRP1 axis as a novel regulatory mechanism driving necroptosis in DE. Targeting this pathway represents a potential therapeutic approach to reduce inflammation and corneal damage in DE.
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Wang et al. (2026) studied this question.
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