PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
February 21, 2026Journal of Pain ResearchOpen Access

Intravenous Pamidronate in Persistent Complex Regional Pain Syndrome (CRPS): A Retrospective Observational Study on Effectiveness and Tolerability

View Full Paper
Ask AI
Bookmark
Share

Authors

DSDaniël van der SpekFHFrank J. P. M. HuygenSHSanne E. Hoeks

Discussion

Loading...

Member takes

Overview

Retrospective observational study shows intravenous pamidronate offers modest pain relief in persistent CRPS, highlighting its tolerability.

Key Points

  • The study aims to assess the effectiveness and tolerability of intravenous pamidronate in patients with persistent complex regional pain syndrome.
  • Single-center retrospective observational study.
  • Included adult patients with persistent CRPS treated with pamidronate from 2014 to 2024.
  • Analyzed pain trajectories using a linear mixed-effects model over follow-up periods.
  • Median baseline NRS pain score was 7.95, decreasing by 1.10 points at 1 month (p<0.001) and 0.66 points at 3 months (p<0.01).
  • Responder rates were 34% at 1 month and 22% at 3 months.
  • 91% of patients experienced treatment-related adverse events, but only 6% discontinued treatment due to side effects.

Cite This Study

Spek et al. (2026) studied this question.

synapsesocial.com/papers/69994ba9873532290d01fd6fhttps://doi.org/10.2147/jpr.s573167
View Full Paper
Ask AI
Bookmark
Share