Experimental trial tests personalized mRNA vaccine to induce immunity in breast cancer, suggesting future therapy avenues.
In an experimental trial, a personalized mRNA vaccine was tested in 14 individuals with an aggressive form of breast cancer. It trained immune cells to target cancer-specific mutant proteins, inducing strong, lasting immunity. Ten participants remained disease-free. Analysis of relapses revealed resistance mechanisms, offering essential insights for future therapies. T cells targeting cancer-specific mutant proteins remained in treated individuals years after vaccination.
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