Ru and Rh binding sites in the structure of human serum transferrin with Fe ³⁺ bound at the C-lobe

Anne‐Sophie Banneville; Giarita Ferraro; Rossella D'Elia; Irina Cornaciu-Hoffmann; Pica Andrea; Antonello Merlino

doi:10.1039/d6dt00205f

January 1, 2026Dalton TransactionsOpen Access

Ru and Rh binding sites in the structure of human serum transferrin with Fe ³⁺ bound at the C-lobe

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Key Points

The study aims to identify the binding sites of Ru and Rh in the structure of human serum transferrin when bound to Fe 3+.
Utilized x-ray crystallography to determine the structure of human serum transferrin
Analyzed the interactions of Ru and Rh with the C-lobe of transferrin
Identified specific side chains, including His and Met, involved in metal binding
Ru and Rh binding sites were successfully identified within the transferrin structure
Several histidine side chains were found to interact with Ru and Rh
Fe 3+ was determined to be bound in the C-lobe, influencing the binding interactions

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Implication

Identifies binding sites for Ru and Rh in human serum transferrin, suggesting insights into metal ion interactions.

Abstract

Ru and Rh binding sites in the structure of human serum transferrin with Fe 3+ bound at the C-lobe were identified by X-ray crystallography. Several His side chains and one Met...

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Cite This Study

Banneville et al. (2026) studied this question.

synapsesocial.com/papers/69994c01873532290d02030b https://doi.org/10.1039/d6dt00205f

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Ru and Rh binding sites in the structure of human serum transferrin with Fe ³⁺ bound at the C-lobe

Key Points

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Implication

Abstract

Discussion

Cite This Study

Ru and Rh binding sites in the structure of human serum transferrin with Fe ³⁺ bound at the C-lobe

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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