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Modular approach demonstrates effective hydroarylation in a safer way, highlighting practical implications.
A modular and practical approach to the Rh(I)-catalyzed hydroarylation of ethylene with arenes bearing a quinoline amide group has been developed. To address the inherent challenges of ethylene hydroarylation, particularly the reliance on high ethylene pressure, this approach employs vinylsilane as a bench-stable, safer surrogate for the in situ generation of ethylene. Comprehensive mechanistic studies support a sequence involving the insertion of vinyl silane, ethylene release, and subsequent hydroarylation, highlighting the efficiency and practicality of this transformation.
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Bangari et al. (2026) studied this question.
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