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Comprehensive analysis uncovers age-related and tissue-specific dynamics in killifish methylation, suggesting its potential in aging studies.
Annual killifish of the genus Nothobranchius are naturally short-lived vertebrates that exhibit a wide range of aging characteristics typically observed in mammals. Here, we provide the first comprehensive whole-genome methylation map for two species, revealing local age-related as well as tissue-specific dynamics in the DNA methylome. Our maps and results support the annual killifish as a model organism and further highlight its value for studying aging including possible health status predictions in vertebrates.
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Steiger et al. (2026) studied this question.
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