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February 21, 2026Magnetic Resonance Materials in Physics Biology and MedicineOpen Access

Accelerated free-breathing volumetric liver proton density fat fraction (PDFF) and R₂^* quantification in pediatric patients using stack-of-radial MRI with multidimensional regularized reconstruction: a retrospective study

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Authors

XZXiaodong ZhongMNMarcel D. NickelBDBrian M. Dale

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Overview

A retrospective study evaluates liver PDFF and R2* mapping in pediatric patients, suggesting accurate and faster imaging techniques.

Key Points

  • To assess an accelerated free-breathing 3D MRI method for quantifying liver PDFF and R2* in pediatric patients.
  • Evaluated stack-of-radial MRI technique on retrospectively undersampled data.
  • Compared results with reference-standard self-gating reconstruction using Bland-Altman analysis.
  • Applied Bayesian posterior analysis to evaluate practical equivalence of mapping results.
  • Achieved reduced image artifacts with the proposed method.
  • Using 176 views showed lower biases for PDFF and R2* compared to using 352 views.
  • The proposed method demonstrated practical equivalence with 100% in PDFF and 98.25% in R2* ROPE, achieving a 67% time saving.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/69994c6f873532290d020ef3https://doi.org/10.1007/s10334-026-01333-y
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