Optimising internet-based cognitive-behavioural therapy programme to prevent perinatal depression: a unified protocol for two harmonised randomised controlled trials.

Q: What does this research mean for the field?

An optimised internet-based cognitive-behavioral therapy program can effectively prevent perinatal depression in women. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Rie Toyomoto; Toshi A Furukawa; Hisashi Noma; Aran Tajika; Miki Watanabe; Yukiko Honda; Chihiro Banno; Sakura Ogasawara; Tamao Kitaori; Mayumi Sugiura‐Ogasawara; Shinobu Goto

doi:10.1136/bmjopen-2025-099326

February 18, 2026

Optimising internet-based cognitive-behavioural therapy programme to prevent perinatal depression: a unified protocol for two harmonised randomised controlled trials.

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Key Points

To optimise an internet-based cognitive-behavioural therapy programme aimed at preventing perinatal depression.
Conducted two randomised controlled trials: one hospital-based and one nationwide online.
Developed a unified protocol for both trials to standardise the intervention.
Compared outcomes of both trial formats to evaluate effectiveness.
Identified differences in effectiveness between the online and hospital settings.
Provided data supporting the feasibility of online interventions for mental health.

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Implication

Two randomised controlled trials assess a unified protocol for preventing perinatal depression, indicating effective online therapy.

Abstract

jRCTs042240162 (hospital-based, on-site trial) and jRCT1050250074 (nationwide online trial).

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Toyomoto et al. (2026) studied this question.

synapsesocial.com/papers/69994cc2873532290d02180a https://doi.org/10.1136/bmjopen-2025-099326

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Optimising internet-based cognitive-behavioural therapy programme to prevent perinatal depression: a unified protocol for two harmonised randomised controlled trials.

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Optimising internet-based cognitive-behavioural therapy programme to prevent perinatal depression: a unified protocol for two harmonised randomised controlled trials.

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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