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February 1, 2026Pathology

Validation and optimisation of a commercial cell-based assay for detection of nodo-paranodal antibodies

Julian Leto Judith Spies Linda Tran Irene Luo Alex Stoyanov Peter Bradhurst Nicolás Urriola

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Key Points

To validate and optimize a commercial assay for detecting nodo-paranodal antibodies in patients with CIDP.
Validation of a commercial cell-based assay
Assessment of autoantibodies against nodal structures
Optimization for improved detection
Autoantibodies identified in a subset of CIDP patients
Patients with these antibodies less likely to respond to IVIg treatment
B cell depletion shows greater effectiveness in patients with nodo-paranodal antibodies

Implication

Validation of a cell-based assay for autoantibodies in CIDP reveals implications for IVIg and B cell depletion.

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Cite This Study

Leto et al. (2026) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268ee1f https://doi.org/10.1016/j.pathol.2026.01.295

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Evaluation and treatment of refractory chronic inflammatory demyelinating polyradiculoneuropathy2025
2Anti-GLDN antibody–associated CIDP (nodopathy): transient IVIg response and B-cell depletion remissionOriginal Research · 2026
3Therapeutic progress and future prospects of chronic inflammatory demyelinating polyradiculoneuropathy2024 · 1 citations
4Advances in the treatment of autoimmune nodopathy: based on treatment strategies of CIDPHuman Clinical Trial · 2026 · 3 citations
5Beyond Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Anti-Contactin-1 Autoimmune Nodopathy Unmasked by ProteinuriaOriginal Research · 2026

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Diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy in clinical practice: A survey among Dutch neurologists2020
Chronic inglammatory demyelinating polyneuropathy (CIDP): a case series from a tertiary center2024
Chronic Inflammatory Demyelinating Polyradiculoneuropathy2026

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