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February 22, 2026Journal of Spinal Cord Medicine0 citationsOpen Access

The role of short-chain fatty acids in spinal cord injury: A systematic review of human and animal evidence

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SRSina RinderknechtABAlessandro BertoloEVEzra Valido

Key Points

  • Examine the therapeutic potential of short-chain fatty acids and gut microbiota in spinal cord injury recovery.
  • Systematic review of existing human and animal studies
  • Analysis of the role of short-chain fatty acids in recovery mechanisms
  • Evaluation of gut microbiota's impact on spinal cord injury outcomes
  • Promising results noted in animal models regarding SCFAs
  • Limited evidence found from human studies on SCFA effectiveness
  • Highlights a need for further human-based research on gut microbiota and SCFAs

Abstract

This review highlights the potential of targeting the gut microbiota and SCFAs as therapeutic strategies for SCI recovery. However, despite promising results in animal models, human evidence remains limited.

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Cite This Study

Rinderknecht et al. (2026) studied this question.

synapsesocial.com/papers/699a9cc6482488d673cd27ddhttps://doi.org/10.1080/10790268.2025.2607831
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  2. 2Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury2020 · 113 citations
  3. 3Sodium Butyrate Exerts Neuroprotective Effects in Spinal Cord Injury2018 · 82 citations
  4. 4Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement2009 · 65,043 citations
  5. 5Association Between Intestinal Microbiota Collected at Hospital Admission and Outcomes of Patients With Cirrhosis2018 · 123 citations