What question did this study set out to answer?

To investigate the pharmacokinetics, withdrawal period, and dietary risk of enrofloxacin in largemouth bass after bath immersion.

February 22, 2026Aquaculture ReportsOpen Access

Pharmacokinetics, withdrawal time, and dietary risk assessment of enrofloxacin in the largemouth bass (Micropterus salmoides) after bath immersion

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Demonstrates the pharmacokinetics and withdrawal time of enrofloxacin in largemouth bass, indicating safety concerns for consumption.

To investigate the pharmacokinetics, withdrawal period, and dietary risk of enrofloxacin in largemouth bass after bath immersion.
Conducted preliminary trials with various enrofloxacin doses (5–40 mg/L).
Administered a 40 mg/L dose for 6 hours for main experiments.
Quantified enrofloxacin and its metabolite using HPLC-FLD and analyzed pharmacokinetics via non-compartmental modeling.
Evaluated maximum residue limit and dietary risk assessment.
Enrofloxacin was rapidly distributed in plasma, muscle, and kidney, with slower liver accumulation.
Half-lives of the drug were approximately 140 hours in plasma and 136 hours in muscle with skin.
A withdrawal period of 37 days is recommended to ensure safety in fish consumption.
Dietary risk indicated a potential health concern within 72 hours post-treatment.

Shan et al. (2026) studied this question.

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