What question did this study set out to answer?

This research aims to develop and evaluate an injectable hydrogel using cyclic peptides for biomedical applications.

February 22, 2026Biomaterials Science1 citationsOpen Access

Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

FSFátima SantillánWestern University YSYasmeen ShamiyaWestern University ACAishik ChakrabortyWestern University

Key Points

This research aims to develop and evaluate an injectable hydrogel using cyclic peptides for biomedical applications.
Developed a cyclic peptide-based hydrogel (cpGel)
Conducted rheological analyses to assess injectability and elasticity
Studied supramolecular interactions between cyclic octapeptide nanofibers and nanosilicates
Demonstrated excellent injectability and elasticity of cpGel
Confirmed significant self-healing properties under specific conditions
Showed that supramolecular interactions enhance the physical performance of the hydrogel

Abstract

An injectable cyclic peptide-based hydrogel (cpGel) governed by supramolecular interactions between cyclic octapeptide nanofibers and nanosilicates was developed. We demonstrated its excellent injectability, elasticity, and self-healing properties through rheological analyses....

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