Copper-Catalyzed Alkylative Deoxygenation of O-Substituted Hydroxamic Acid Derivatives with Grignard Reagents: A Combined Experimental and Computational Study
Experimental and computational study demonstrates reactivity of hydroxamic acid derivatives with Grignard reagents, suggesting new insights into catalytic mechanisms.
Key Points
This research aims to explore the copper-catalyzed electrophilic amidation involving Grignard reagents and hydroxamic acid derivatives.
Utilized CuCN as a catalyst for reaction with Grignard reagents.
Examined structural nature of organomagnesium cuprates through experimental evidence.
Performed DFT computational analysis to investigate reaction mechanisms.
Created secondary amides from O-allyl- and O-benzyl-hydroxamic acid derivatives.
Identified the formation of electrophilic acyl nitrenoid species during reaction.
Provided insights into the molecular composition and reactivity of organomagnesium cuprates.