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Synapse
February 22, 2026Current Opinion in Neurology0 citationsOpen Access

AI in epilepsy neuroimaging

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SASophie AdlerKWKonrad Wagstyl

Key Points

  • This review aims to explore the advancements in AI applied to epilepsy neuroimaging.
  • Reviewed various AI architectures and machine learning approaches
  • Assessed applications like prediction of epilepsy, lesion detection, and localization of seizure onset zones
  • Evaluated tools for image enhancement and surgical planning
  • Identified successful machine learning methods for epilepsy prediction and lesion detection
  • Highlighted open and validated AI tools for diverse clinical settings
  • Discussed emerging applications and challenges in clinical integration of AI tools

Abstract

Purpose of review Recent advances in the capabilities and usability of artificial intelligence (AI) architectures coupled with increased availability of neuroimaging datasets has fuelled a rapid expansion in AI applications to epilepsy neuroimaging. This review summarizes the main applications of AI in epilepsy neuroimaging and suggests future directions for the field. Recent findings A range of different machine learning approaches, from multi-layer perceptrons to volumetric and graph-based convolutional neural networks, have been utilized for prediction of whether people will have epilepsy, detection of structural epilepsy lesions, localization of seizure onset zones, segmentation of resection cavities after epilepsy surgery as well as for image enhancement. Summary AI in epilepsy neuroimaging research has primarily focussed on lesion detection and localization, with a number of open and validated tools now available for evaluation across diverse settings. Additional applications of AI in epilepsy neuroimaging are either at earlier stages of development or emerging as new challenges. As these tools and their supporting evidence mature, further work addressing the hurdles of clinical integration is required.

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Cite This Study

Adler et al. (2026) studied this question.

synapsesocial.com/papers/699a9d65482488d673cd3427https://doi.org/10.1097/wco.0000000000001465
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