We identified 5790 statistically significant circRNAs that were differentially expressed between benign and cancerous cervical tissues; circ₀123115 (log2FC = 5. 10, p = 1. 66 × 10-55), associated with FGF12, was the most significant. Comparing benign to precancerous tissues, we found 1439 circRNAs with statistically significant differential expression, with circ₀100775 (log2FC = 2. 13, p = 1. 38 × 10-18), associated with TDRD3, being the most significant. Between precancerous and cancerous tissues, 4915 circRNAs were differentially expressed with statistical significance; circ₀006038 (log2FC = 4. 74, p = 1. 22 × 10-40), associated with STXBP6, was the most significant. In a three-way comparison, 57, 749 circRNAs were differentially expressed, with circ₀106394 (p = 3. 02 × 10-21), associated with USP22, being the most significant. Our study identified circRNAs with significant differential expression across benign, precancerous, and cancerous cervical tissues, demonstrating their potential role in cervical cancer progression.
Zhong et al. (Thu,) studied this question.