Pulsed field ablation for AF causes less autonomic nervous system disruption and neural damage than thermal ablation, with effects sustained mid- to long-term.
Does pulsed field ablation (PFA) reduce disruption of the autonomic nervous system compared to thermal ablation in patients with atrial fibrillation?
Pulsed field ablation causes less disruption to the cardiac autonomic nervous system than thermal ablation in patients with atrial fibrillation.
Absolute Event Rate: 0% vs 0%
Aims: Ablation modalities differ in their mechanisms of action, tissue specificity, and collateral effects-particularly on the cardiac autonomic nervous system. This study aimed to compare the autonomic effects of pulsed field ablation (PFA) vs. thermal ablation (TA) in patients with atrial fibrillation (AF) through a pooled analysis. Conclusion: PFA-based pulmonary vein isolation in patients with AF results in a smaller post-procedural IHR and less S100B release, suggesting reduced neural damage and less disruption of the autonomic nervous system compared to TA. These effects are sustained through mid- to long-term follow-up and may have potential implications for patient selection and individualized ablation strategies.
Graeger et al. (Fri,) reported a other. Pulsed field ablation for AF causes less autonomic nervous system disruption and neural damage than thermal ablation, with effects sustained mid- to long-term.