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February 22, 2026Clinical Cancer Research

Abstract PS2-09-20: Circulating Tumor DNA Dynamics and Anatomical Patterns of Relapse Following Curative Therapy in Early-Stage Breast Cancer

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Authors

DSD. G. StoverBDB. K. DwivediPDP. Dutta

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Overview

Retrospective study explores relapse patterns in early-stage breast cancer, indicating potential for ctDNA monitoring strategies.

Key Points

  • This study aims to predict anatomical relapse patterns in early-stage breast cancer based on ctDNA detection and molecular characteristics.
  • Conducted a retrospective analysis of 532 early-stage breast cancer patients using real-world databases.
  • Examined ctDNA detection rates in relation to tumor subtype and anatomical site of relapse.
  • Categorized patients by anatomical sites of recurrence and analyzed ctDNA dynamics over time.
  • Identified 91% ctDNA positivity prior to or at the time of recurrence across subtypes.
  • Most common relapse sites were bone and lung, with rates reflecting tumor subtype.
  • Median ctDNA levels were highest in TNBC patients, indicating significant differences by subtype.

Cite This Study

Stover et al. (2026) studied this question.

synapsesocial.com/papers/699a9dc0482488d673cd3d79https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-20
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