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Demonstrates enhanced binding affinity of p53 mimetics to MDM2, suggesting new cancer treatment strategies.
Triazole-stapled p53 peptides effectively block the oncogenic p53–MDM2 interaction by strengthening peptide–protein contacts and water-mediated interactions. Stapling at positions 4–11 enhances the binding affinity of p53 towards MDM2.
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Gaikwad et al. (2026) studied this question.
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