A One-Step Chemical Derivatization Strategy for Mass Spectrometric Characterization of Synthetic Mimetics of Sulfated Glycosaminoglycans

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A novel one-step methodology enables direct mass spectrometric characterization of sulfated non-saccharide glycosaminoglycan mimetics. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

C.S. Sharma; Daniel K. Afosah; Bharath Kumar Villuri; U. R. Desai

doi:10.1039/d5ay01855b

January 1, 2026Analytical Methods

A One-Step Chemical Derivatization Strategy for Mass Spectrometric Characterization of Synthetic Mimetics of Sulfated Glycosaminoglycans

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Key Points

To develop a one-step chemical derivatization strategy for mass spectrometric analysis of synthetic mimetics.
Utilized trifluorodiazoethane for derivatization
Performed mass spectrometric characterization of sodiated forms
Focused on sulfated non-saccharide glycosaminoglycan mimetics
Successfully characterized the chemical structure of mimetics
Demonstrated enhanced hydrophobic properties using the methodology
Achieved effective mass spectrometric analysis in a single step

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Implication

Novel one-step methodology characterizes sulfated glycosaminoglycan mimetics, suggesting an efficient analytical approach.

Abstract

We present a novel one‐step methodology for direct mass spectrometric characterization of sulfated non‐saccharide glycosaminoglycan mimetics in their sodiated form using the high reactivity of trifluorodiazoethane to form hydrophobic and...

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Sharma et al. (2026) studied this question.

synapsesocial.com/papers/699a9e2d482488d673cd4b4c https://doi.org/10.1039/d5ay01855b

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A One-Step Chemical Derivatization Strategy for Mass Spectrometric Characterization of Synthetic Mimetics of Sulfated Glycosaminoglycans

Key Points

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Implication

Abstract

Discussion

Cite This Study

A One-Step Chemical Derivatization Strategy for Mass Spectrometric Characterization of Synthetic Mimetics of Sulfated Glycosaminoglycans

Key Points

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Implication

Abstract

Discussion

Cite This Study

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