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February 23, 2026International Journal of Preventive and Clinical Dental Research0 citationsOpen Access

Impact of Oral Hygiene on Carcinogenesis Risk Related to Periodontal Pathogens

Effect of poor oral hygiene and periodontal pathogens on the risk of oral carcinogenesis

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Authors

NPNirav H. ParekhSSrishti

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Overview

Cross-sectional study reveals poor oral health relates to increased genomic instability in oral mucosa, suggesting links to cancer risk.

Key Points

  • This research investigates the association between oral hygiene, periodontal pathogens, and genomic indicators linked to oral cancer.
  • Cross-sectional comparative study involving 150 individuals across three groups based on oral health status.
  • Assessment of oral hygiene using the Oral Hygiene Index-Simplified and periodontal factors.
  • Micronucleus and nuclear abnormalities measured through exfoliative cytology of buccal mucosa.
  • Subgingival plaque analyzed for specific periodontal pathogens using polymerase chain reaction.
  • Group A displayed significantly higher micronucleus frequency at 17.6 per 1000 cells compared to Group B (10.2) and Group C (3.8).
  • Nuclear abnormalities were most prevalent in Group A (70%), with lower frequencies in Groups B (46%) and C (12%).
  • P. gingivalis and F. nucleatum were most commonly found in Group A at rates of 60% and 66%, respectively.
  • A positive correlation between micronucleus frequency and probing pocket depth was identified.

Cite This Study

Parekh et al. (2025) studied this question.

synapsesocial.com/papers/699ba0a772792ae9fd8709a6https://doi.org/10.4103/ijpcdr.ijpcdr_4_26
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