In the present study, we have developed a Baker’s yeast (BY) mediated efficient and mild nitration of aromatic compounds. The results of nitration clearly showed that it is a highly regio-selective method, when aromatic compounds (1a–1h) were nitrated by using the BY/nitric acid system and gave corresponding nitro derivatives (2a–2h) in good to excellent yield. The present reaction condition is advantageous as it follows a normal procedure and requires a simple workup, adhering to green chemistry principles. Thus, we can conclude that the present nitration method is a simple, efficient, regio-selective, and eco-friendly method under bio-catalysis conditions.
Ullah et al. (Mon,) studied this question.