The research demonstrates that first-line antibiotics are more effective than alternatives in preventing neonatal sepsis from GBS.
Strongly encourage pregnant women with the history of a penicillin allergy to undergo prenatal allergy testing as first-line intrapartum antibiotic prophylaxis for group B strep (GBS) is superior to second-line or no antibiotics, which have similar rates of early onset sepsis (EOS).
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Gray et al. (2025) studied this question.
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