Unique clinical and radiological features in patients with moyamoya disease under 4 years of age: a multicenter MACINTOSH Study in Japan

Satoshi Kuroda; Shoko Hara; Jyo Matsuzaki; Yoshio Araki; Ryuta Saito; Eika Hamano; Hiroharu Kataoka; Satoshi Murai; Tomohito Hishikawa; Masaki Ito; Haruto Uchino; Miki Fujimura; Ryosuke Tashiro; Atsushi Kanoke; Hidenori Endo; Koji Yamaguchi; Shunsuke Nomura; Akitsugu Kawashima; Takakazu Kawamata; Shusuke Yamamoto; Daina Kashiwazaki; Emiko Hori; Ataru Nishimura; Koji Yoshimoto; Yasushi Takagi; Satoru Miyawaki; Nobuhito Saito; Jun Takahashi; Taketoshi Maehara; Susumu Miyamoto

doi:10.3171/2025.10.peds25480

Key Points

The research aims to identify specific clinical and radiological features in young patients with moyamoya disease.
Conducted a multicenter observational study across various sites in Japan.
Focused on patients under 4 years of age, particularly those under 1 year.
Analyzed both demographic and clinical data along with radiological imaging results.
Identified very specific demographic, clinical, and radiological characteristics in young patients.
Detected artery-to-artery embolism and hemodynamic ischemia even at early disease stages (Suzuki stage 2).
Revealed a significant risk of TIA and ischemic stroke due to these mechanisms.

Implication

Multicenter study demonstrates specific characteristics of moyamoya disease in young children, indicating unique clinical implications.

Abstract

This study demonstrated that demographic, clinical, and radiological characteristics are very specific in patients with moyamoya disease under 4 years of age, especially those under 1 year. Even a very early disease stage (Suzuki stage 2) could provoke TIA and/or ischemic stroke through the mechanism of artery-to-artery embolism as well as hemodynamic ischemia. Clinical trial registration no.: UMIN000040169 (www.umin.ac.jp).

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Cite This Study

Kuroda et al. (2026) studied this question.

synapsesocial.com/papers/699bee551c6c6bad53980038 https://doi.org/10.3171/2025.10.peds25480

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Unique clinical and radiological features in patients with moyamoya disease under 4 years of age: a multicenter MACINTOSH Study in Japan

Key Points

Implication

Abstract

Discussion

Cite This Study

Unique clinical and radiological features in patients with moyamoya disease under 4 years of age: a multicenter MACINTOSH Study in Japan

Key Points

Implication

Abstract

Discussion

Cite This Study

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