What does this research mean for the field?

Many urological RCTs with non-significant primary outcomes still hold valuable insights that can be extracted through further investigation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore how to interpret non-significant results in urological trials effectively.

February 25, 2026BJU International1 citations

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Urological trials without significant results. Can we extract meaning from disappointment?

DNDarcy NollLyell McEwin Hospital PSPeter StapletonLyell McEwin Hospital MOMichael O'CallaghanFlinders University

Key Points

This research aims to explore how to interpret non-significant results in urological trials effectively.
Review of various urological randomized controlled trials
Assessment of statistical significance in primary outcomes
Application of the likelihood ratio to enhance result interpretation
Numerous trials reported primary outcomes that lacked statistical significance
Using the likelihood ratio improved the understanding of these results
Further investigation is recommended for trials with non-significant findings

Abstract

Many urological RCTs with primary outcomes that were not statistically significant by traditional measures warrant further investigation. Researchers should apply the LR to future trials to aid interpretation of their results.

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Urological trials without significant results. Can we extract meaning from disappointment?

Key Points

Abstract

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