A hemodynamic-driven approach to chronic pulmonary hypertension in congenital diaphragmatic hernia

Despite ample research in acute pulmonary hypertension in neonates with congenital diaphragmatic hernia (CDH) leading to improved survival, there is a paucity of literature on the physiology of chronic pulmonary hypertension in this population. Serial hemodynamic assessments and physiology-centric care have been shown to be safe and effective in the acute transitional and peri-operative care of these neonates and will likely be informative in the discussion of chronic pulmonary hypertension as well. Herein, we discuss the epidemiology, contributors, and proposed physiology-based phenotypes of chronic pulmonary hypertension in neonates with CDH. Further investigation is needed to contribute to our understanding and treatment of chronic pulmonary hypertension in this complex, heterogeneous population.