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February 25, 20260 citations

The value of gender -specific baseline CT body composition quantitative parameters in assessing the efficacy of R-CHOP chemotherapy in DLBCL.

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YAYueming AnShandong UniversityPWPing WeiThe Eighth Hospital of Xi'anLZLiping ZuoQilu Hospital of Shandong University

Key Points

  • To assess how gender-specific body composition parameters influence the effectiveness of R-CHOP chemotherapy in DLBCL patients.
  • Analyzed changes in VAT and SAT volumes in male patients
  • Evaluated SM volume impact on female patients
  • Compared body composition metrics against treatment outcomes
  • Increased VAT volume and SAT volume density correlate with poorer chemotherapy efficacy in males.
  • In females, higher SM volume is associated with worse outcomes from R-CHOP chemotherapy.

Abstract

Increased VAT volume and SAT volume density are linked to poor efficiency in male DLBCL patients, while increased SM volume relates to poor outcomes in females. Sex differences in body composition play a crucial role in personalized DLBCL treatment.

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Cite This Study

An et al. (2026) studied this question.

synapsesocial.com/papers/699e911bf5123be5ed04e742https://doi.org/10.1080/00325481.2026.2633463
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