Metastatic Impact of Perfluorooctanoic Acid on Liver Cancer: Insights from HepG2 Cells and Zebrafish Xenograft Models

Kayla Hawn; Emma Kenyon; Gregory Buck; Wei Xu

doi:10.1039/d5va00491h

January 1, 2026Environmental Science AdvancesOpen Access

Metastatic Impact of Perfluorooctanoic Acid on Liver Cancer: Insights from HepG2 Cells and Zebrafish Xenograft Models

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to investigate the role of perfluorooctanoic acid (PFOA) in liver cancer progression.
Utilized HepG2 cells to study cellular responses to PFOA exposure.
Implemented zebrafish xenograft models to assess tumor development and metastasis.
Conducted comparative analyses of cancer cell behavior under PFOA influence.
PFOA exposure increased metastatic traits in HepG2 cells.
Zebrafish models showed enhanced tumor growth with PFOA treatment.
Findings suggest a clear link between PFOA and liver cancer progression.

Implication

Demonstrates the effects of PFOA on liver cancer in liver cells and zebrafish models, suggesting harmful implications for cancer progression.

Abstract

Widely used in consumer products for their water- and grease-resistant properties, perfluorooctanoic acid (PFOA), a legacy per- and polyfluoroalkyl substance (PFAS), has been increasingly implicated in liver carcinogenesis. Long-term or...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hawn et al. (2026) studied this question.

synapsesocial.com/papers/699e912ef5123be5ed04e8f7 https://doi.org/10.1039/d5va00491h

View Full Paper

Ask AI

Bookmark

Share

Metastatic Impact of Perfluorooctanoic Acid on Liver Cancer: Insights from HepG2 Cells and Zebrafish Xenograft Models

Key Points

Implication

Abstract

Discussion

Cite This Study

Metastatic Impact of Perfluorooctanoic Acid on Liver Cancer: Insights from HepG2 Cells and Zebrafish Xenograft Models

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading