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February 25, 2026Journal of Materials Chemistry B0 citations

Injectable Hydrogel-Based Localized Delivery of IDO-Galectin-3 Mitigates Neuroinflammation and Promotes Neuronal Sparing After Spinal Cord Contusion in Rats

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GAGopal Surajbhan AgarwalAGAllison A GalbraithAWArun Wanchoo

Key Points

  • To evaluate the effects of localized delivery of IDO-Galectin-3 on neuroinflammation and neuronal preservation after spinal cord injury.
  • Used a hydrogel-based delivery system for IDO-Galectin-3
  • Conducted experiments on rats with spinal cord contusion
  • Measured neuroinflammatory markers and axonal regeneration
  • Assessed functional recovery post-intervention
  • Significant reduction in neuroinflammation observed
  • Enhanced axonal regeneration noted
  • Improved functional recovery in treated rats compared to controls

Abstract

Traumatic spinal cord injury (SCI) results in excessive neuroinflammation characterized by secondary injury cascades, which hinders axonal regeneration and impairs functional recovery. Here, we sought to deliver an anti-inflammatory enzyme,...

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Cite This Study

Agarwal et al. (2026) studied this question.

synapsesocial.com/papers/699e9143f5123be5ed04eb3dhttps://doi.org/10.1039/d5tb02228b
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