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February 25, 2026Cell Communication and SignalingOpen Access

Activation of aryl hydrocarbon receptor alleviates cholestatic liver injury by inhibiting inflammation

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Authors

QHQi HanLWLikai WangXYXuzhen Yan

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Overview

This research examines AHR's role in reducing cholestatic liver injury by modulating inflammation mechanisms in mouse models.

Key Points

  • The aim is to explore the role of AHR in cholestatic liver injury and the mechanisms of its activation disruption.
  • Used mouse models of cholestatic liver injury induced by DDC diet or bile duct ligation.
  • Administered tryptophan-derived agonist ITE for pharmacological AHR activation.
  • Performed transcriptomic analysis and 16 S rDNA sequencing for mechanistic insights.
  • Utilized AAV-mediated AHR overexpression to assess effects on liver injury.
  • Pharmacological activation of AHR reduced liver injury and inflammation markers.
  • Transcriptomic analysis showed ITE treatment decreased chemokine and inflammatory gene expression.
  • Activated AHR repressed CCL2 transcription, lowering inflammatory cell recruitment.
  • Cholestasis altered gut microbiota influencing tryptophan metabolism and AHR activation.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/699e9152f5123be5ed04ed28https://doi.org/10.1186/s12964-026-02755-w
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