Biodegradable Prussian blue/manganese dioxide core–shell nanoparticles with open cages for imaging-guided chemo-photothermal combined therapy of cancer cells

Ying Gao; Jinbo Xue; Yuebo Yang; Dongxiao Bian; Luyao Liu; Luyao Liu; Ming Zhu; Tao Yang; Le Liu; Le Liu

doi:10.1039/d5ra07493b

January 1, 2026RSC AdvancesOpen Access

Biodegradable Prussian blue/manganese dioxide core–shell nanoparticles with open cages for imaging-guided chemo-photothermal combined therapy of cancer cells

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Key Points

The research aims to develop biodegradable nanoparticles that enhance imaging and therapy for cancer treatment.
Developed PBMn core–shell nanoplatform with an open cage design.
Utilized Prussian blue for photothermal therapy.
Employed manganese dioxide to enhance MRI capabilities.
Tested combined chemo-photothermal therapy on cancer cells.
Demonstrated effective imaging-guided therapy using the PBMn nanoparticles.
Achieved significant cancer cell death with the combined treatment approach.

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Implication

Nanoparticles enhance imaging and therapy in cancer cells, suggesting a novel combined treatment approach.

Abstract

The open cage-like Prussian blue/manganese dioxide (PBMn) core–shell nanoplatform utilizes its PB core for photothermal therapy and its MnO 2 shell to enhance MRI, enabling imaging-guided synergistic chemo-photothermal therapy.

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Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/699e918df5123be5ed04f28d https://doi.org/10.1039/d5ra07493b

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Biodegradable Prussian blue/manganese dioxide core–shell nanoparticles with open cages for imaging-guided chemo-photothermal combined therapy of cancer cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Biodegradable Prussian blue/manganese dioxide core–shell nanoparticles with open cages for imaging-guided chemo-photothermal combined therapy of cancer cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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