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February 25, 2026HippocampusOpen Access

Layer‐Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus‐Induced Encephalitis

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Authors

DMDiego de Almeida MirandaASAline Andrade de SousaRRRenata Rodrigues dos Reis

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Overview

Characterizes astrocyte morphological responses in CA3 hippocampus during viral encephalitis, indicating distinct vulnerabilities.

Key Points

  • To investigate whether astrocytes from different hippocampal layers show unique morphological responses to Piry virus-induced encephalitis.
  • Inoculated adult female Swiss mice with Piry virus intranasally.
  • Sacrificed mice at 20 or 40 days post-infection for analysis.
  • Conducted 3D reconstructions of GFAP+ astrocytes from specific layers.
  • Employed hierarchical clustering, linear discriminant analysis (LDA), and generalized linear models for evaluation.
  • Identified 3-4 distinct astrocyte morphotypes per layer and time point.
  • At 20 dpi, SLM astrocytes were significantly more complex than SO astrocytes.
  • Responses at 40 dpi were more heterogeneous, indicating changing astrocyte reactivity over time.

Cite This Study

Miranda et al. (2026) studied this question.

synapsesocial.com/papers/699e919cf5123be5ed04f402https://doi.org/10.1002/hipo.70085
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