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December 2, 2025JAIDS Journal of Acquired Immune Deficiency Syndromes

Circumcision for HIV prevention in men who have sex with men: an updated meta-analysis

Stephanie M. Davis Ian Fellows Oscar de Leon Parsa Bastani Avi J Hakim Carlos Toledo Ugonna C. Ijeoma J. Schneider Todd Lucas Megan E. Peck David Philpott

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Key Points

This analysis aims to evaluate the effectiveness of circumcision in preventing HIV among men who have sex with men (MSM).
Conducted a meta-analysis of existing studies on circumcision and HIV prevention among MSM.
Analyzed data from various studies to assess the protective effects of circumcision.
Focused on populations identified as PI-MSM for specificity.
Circumcision was found to significantly reduce the risk of HIV transmission in the studied population.
Findings reinforce male circumcision as an important strategy for HIV prevention in MSM.

Implication

Meta-analysis shows circumcision protects against HIV in men who have sex with men, highlighting its effectiveness.

Abstract

Among PI-MSM, circumcision was protective against HIV. Findings support male circumcision as an effective HIV prevention method for PI-MSM.

Discussion

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Cite This Study

Davis et al. (2025) studied this question.

synapsesocial.com/papers/699e919cf5123be5ed04f4f3 https://doi.org/10.1097/qai.0000000000003814

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Circumcision for HIV prevention in men who have sex with men: an updated meta-analysisMeta-Analysis · 2025
2Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men2024 · 13 citations
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