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February 25, 20260 citations

Hazelnut oral immunotherapy in children: An Italian single-center retrospective cohort study.

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SBSimona BarniBPBenedetta PessinaSFSerena Della Femina

Key Points

  • The aim is to evaluate the efficacy and safety of hazelnut oral immunotherapy (H-OIT) in children with hazelnut allergies (HA).
  • Conducted a retrospective cohort study at a single center
  • Included children diagnosed with hazelnut allergies
  • Analyzed rates of discontinuation and anaphylactic events
  • One quarter of patients maintained a lower, partial dose of H-OIT
  • Overall safety profile deemed acceptable despite anaphylactic events
  • High rate of discontinuation was noted among participants

Abstract

H-OIT may be an effective treatment option for children with HA despite the high discontinuation rate. One quarter of patients remained on a lower, partial maintenance dose. Although the overall safety profile of H-OIT seems acceptable, anaphylactic events represent a significant burden for families and must be carefully considered when weighing the risks and benefits of OIT.

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Cite This Study

Barni et al. (2026) studied this question.

synapsesocial.com/papers/699e91b2f5123be5ed04f6cbhttps://doi.org/10.1111/pai.70287
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