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Demonstrates the inhibition of quorum sensing in Staphylococcus aureus, suggesting a new avenue for controlling bacterial virulence.
We report the synthesis and characterization of a small molecule, CP-20, capable of inhibiting the key quorum sensing receptor AgrC in Staphylococcus aureus. Structural alterations enabled the discovery of a CP-20 derivative that is capable of complete quorum sensing inhibition with mid-nanomolar potency. In vitro biochemical investigations support CP-20 binding AgrC and competitively inhibiting its activity. CP-20 represents a versatile and synthetically tractable small molecule probe for investigating Staphylococcal virulence via quorum sensing modulation.
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Polaske et al. (2026) studied this question.
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