What question did this study set out to answer?

The aim is to investigate the genomic factors driving resistance and virulence in Klebsiella pneumoniae isolates.

February 25, 20260 citationsOpen Access

Genomic evidence of convergence of multidrug resistance and enhanced virulence in carbapenem- and colistin-resistant Klebsiella pneumoniae from Turkey

Key Points

The aim is to investigate the genomic factors driving resistance and virulence in Klebsiella pneumoniae isolates.
Analyzed whole-genome sequencing of Klebsiella pneumoniae isolates.
Utilized single-nucleotide polymorphism (SNP) analysis to identify genetic backgrounds.
Assessed antimicrobial resistance genes and plasmid profiles across various sequence types.
Identified specific sequence types associated with multidrug resistance and virulence.
Revealed the prevalence of various antimicrobial resistance genes across the isolates.
Showed clustering of resistant isolates based on genomic similarities.

Abstract

Supplemental MaterialFigure S1. Clustering of ST2096 and ST8972 isolates based on whole-genome single-nucleotide polymorphisms (SNPs).Figures S2 to S6. Genetic background of antimicrobial resistance genes in the 44 Klebsiella pneumoniae draft genomes.Table S1. Distribution of core genome MLST (cgMLST) types across sequence types (STs) in Klebsiella pneumoniae isolates.Table S2. Genomes from the Pathogenwatch platform used to draw cgMLST tree.Table S3. Genomes from the Pathogenwatch platform used to draw SNP-based trees.Table S4. Genomic characterization of Klebsiella pneumoniae isolates collected in this study.Table S5. Demographic and genomic characteristics of the 44 genomes studied in the present study.Table S6. Prevalence of antimicrobial resistance genes stratified by antimicrobial class.Table S7. Prevalence and distribution of antimicrobial resistance profiles stratified by MLST type among Klebsiella pneumoniae isolates in this study.Table S8. Distribution and prevalence of plasmid replicon types among the 44 Klebsiella pneumoniae isolates in this study.Table S9. Prevalence and distribution of plasmid profiles stratified by MLST type among Klebsiella pneumoniae isolates in this study.Table S10. Distribution and genomic locations of antimicrobial resistance genes in the 44 Klebsiella pneumoniae genomes analyzed.Table S11. Circulating Sequence Types and Resistance Mechanisms of Carbapenem- and/or Colistin-Resistant Klebsiella pneumoniae in Turkish Studies (2010–2025).

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