Adamantane-Based Inhibitors of the Influenza A M2 Proton Channel: Structure-Based Design, Biological Evaluation, and Synthetic Approaches

Μarianna Stampolaki; Maria Kouridaki; Kyriakos Georgiou; Antonios Kolocouris

doi:10.1039/d5md01027f

January 1, 2026RSC Medicinal ChemistryOpen Access

Adamantane-Based Inhibitors of the Influenza A M2 Proton Channel: Structure-Based Design, Biological Evaluation, and Synthetic Approaches

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Key Points

To design and evaluate adamantane-based inhibitors targeting the influenza A M2 proton channel.
Utilized structure-based design to create inhibitors.
Conducted biological evaluations to test inhibitor efficacy.
Applied solid-state NMR and X-ray crystallography for structural analysis.
Identified effective adamantane-based inhibitors of the M2 proton channel.
Demonstrated the ability of these inhibitors to block proton conduction.
Revealed insights into the structure-function relationship of the M2 protein.

Implication

Research explores inhibitors that target the M2 proton channel in influenza A, indicating potential treatment avenues.

Abstract

The influenza A matrix 2 (AM2) protein, a prototype of viroporins, conducts protons along a chain of water molecules and ionizable side chains, including histidine-37. Solid-state NMR (ssNMR) and X-ray...

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Cite This Study

Stampolaki et al. (2026) studied this question.

synapsesocial.com/papers/699e920af5123be5ed04ff92 https://doi.org/10.1039/d5md01027f

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Adamantane-Based Inhibitors of the Influenza A M2 Proton Channel: Structure-Based Design, Biological Evaluation, and Synthetic Approaches

Key Points

Implication

Abstract

Discussion

Cite This Study

Adamantane-Based Inhibitors of the Influenza A M2 Proton Channel: Structure-Based Design, Biological Evaluation, and Synthetic Approaches

Key Points

Implication

Abstract

Discussion

Cite This Study

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